MOSTI's MyGenom Project Targeting Collection Of 10,000 Genome Sequence For Local Genetic References

SHAH ALAM, Aug 29 (Bernama) -- The government is targeting a collection of 10,000 genomic sequences through the MyGenom project to create an accurate reference for local genetics to enhance health delivery. 

Minister of Science, Technology, and Innovation Chang Lih Kang stated that the project aims to establish a reference genome based on healthy individuals, acknowledging that most current human genomic studies focus on populations from Europe, America, or East Asia.

He noted that the project is now in its first phase, which involves developing standard operating procedures for sampling, quality control, DNA extraction, and sequencing to ensure compliance with established standards.

"The MyGenom project will be implemented in phases, with the first phase involving the sequencing of 2,500 genomes, expected to be completed by 2025.

"After that, we will seek approval in the 13th Malaysia Plan (RMK-13) to achieve 10,000 genomic sequences, representing a ratio of 1 in 3,300 of the Malaysian population," he said at a press conference after the launch of the project today. Also present was Health Minister Datuk Seri Dr. Dzulkefly Ahmad.

Genome sequencing is the process of determining the precise order of nucleotides in a DNA molecule, which encodes genetic information about the body. This process offers insights into how individual genes function and their impact on human health and well-being.

Chang stated that the MyGenom database will also be developed to enable organised and systematic access to and sharing of genomic data for numerous purposes, including analysis, research, diagnostics, and clinical applications among researchers and stakeholders.

"Healthy genome sequencing helps establish a baseline of normal genetic variation, which is essential for distinguishing genetic variations that may cause disease, thus enhancing the accuracy of genetic data interpretation.

"Sequencing the genomes of healthy populations can also help identify genetic factors contributing to health and physical resilience, which can be utilised as public health strategies and lifestyle recommendations to support well-being and disease prevention," he said.

Meanwhile, Dzulkefly noted that the project, which opens significant opportunities for precision medicine in Malaysia, would also enable local health institutions to provide more effective treatments.

"For instance, in the treatment of diabetes treatment, genetic information can be used to predict a patient's response to specific medications, be it oral hypoglycemic agents or insulin.

"Precision medicine allows patients to be prescribed the most effective drugs earlier, reduces side effects, and enables the best long-term health outcomes," he emphasised.

The MyGenom project is led by researchers from agencies under the Ministry of Science, Technology, and Innovation (MOSTI) in collaboration with the Ministry of Health Malaysia (MOH), Malaysia Genome and Vaccine Institute, National Institutes of Biotechnology Malaysia, Institute for Medical Research, and the National Institutes of Health.

The MyGenom project team from MOH will employ three sampling strategies: continuous sampling at seven blood donation centres in selected hospitals nationwide, periodic sampling at three blood donation centres in selected hospitals, and targeted community sampling.

-- BERNAMA