UTS-led Research Develops Nanoparticles Targeting Disease Proteins

KUALA LUMPUR, Jan 22 (Bernama) -- University of Technology Sydney (UTS) Chair Professor in Nanomedicine Bingyang Shi and international collaborators have developed a novel nanoparticle-based approach aimed at targeting disease-causing proteins in the body.

Published in Nature Nanotechnology, the perspective article describes engineered nanoparticles, known as nanoparticle-mediated targeting chimaeras (NPTACs), which can be customised to bind and degrade specific proteins linked to diseases such as cancer and dementia, according to UTS in a statement.

Professor Shi said these nanoparticles are designed to guide harmful proteins into the body’s natural recycling system, where they can be broken down and removed, adding that while promising, this research remains at the preclinical stage, and further studies are required before any clinical application.

The technology builds on the concept of targeted protein degradation, a growing field in biotechnology, and could eventually expand the range of proteins considered "undruggable". Early preclinical experiments have shown potential against key disease targets, including EGFR and PD-L1, which are implicated in tumour growth and immune evasion.

Key advantages of the approach include tissue- and disease-specific targeting, the ability to cross the blood–brain barrier, modular design for multiple protein targets, and compatibility with Food and Drug Administration (FDA)-approved nanomaterials.

Professor Shi highlighted that NPTACs are still in the experimental phase, and the team is seeking strategic partners to support further development, regulatory review, and potential therapeutic applications in oncology, neurology, and immunology.

Professor Shi noted that this research illustrates the potential of nanoparticle-based platforms not just as delivery vehicles but as active therapeutic agents.

The work involved collaboration with Professor Kam Leong of Columbia University and Professor Meng Zheng of Henan University.

-- BERNAMA